Relationship between body mass index, cardiovascular biomarkers and incident heart failure

Aims There are limited data examining whether body mass index (BMI) influences the association between cardiovascular biomarkers and incident heart failure (HF). Methods results Thirteen representing key HF domains were measured: N-terminal pro-B-type natriuretic peptide (NT-proBNP), mid-regional pro-A-type (MR-proANP), cardiac troponin T (cTnT), C-reactive protein, procalcitonin, galectin-3, C-terminal pro-endothelin-1 (CT-proET-1), pro-adrenomedullin, plasminogen activator inhibitor-1, copeptin, renin, aldosterone, cystatin-C. Associations of with BMI examined using linear regression models, Cox models. We selected significantly associated HF, evaluated modified these associations. Among 8202 individuals, 41% overweight (BMI 25–30 kg/m2), 16% obese ?30 kg/m2). Mean age cohort was 49 years (range 28–75), 50% women. All except renin BMI: inverse associations observed NT-proBNP, MR-proANP, CT-proET-1 aldosterone whereas positive remaining (all P ? 0.001). During 11.3 ± 3.1 follow-up, 357 events recorded. Only MR-proANP cTnT remained (P < 0.001), a significant biomarker*BMI interaction not (interaction > 0.1). Combined NT-proBNP measurements modestly improved performance metrics clinical model in (?C-statistic = 0.024; likelihood ratio ?2 38; 0.001) 0.020; 32; individuals. Conclusions Plasma concentrations several influenced by obesity. did modify A combination improves risk prediction